Synthesis and Characterization of Thermosensitive PNIPAM Microgels covered with Superparamagnetic γ-Fe2O3 iron oxide Nanoparticles
Jorge Rubio-Retama¹, Nikolaos E. Zafeiropoulos¹, Caterina Serafinelli¹, Rosana Rojas-Reyna¹, Brigitte Voit, E. Lopez Cabarcos¹, and Manfred Stamm¹; Langmuir 2007, 23, 10280-10285.
Abstract: In the present study we report a facile and reproducible method of preparing magnetic thermosensitive hybrid material based on P(NIPAM) microgels covered with γ-Fe2O3 iron oxide nanoparticles of 6-nm size. The iron oxide nanoparticles provided magnetic response to the microgels. In addition, the presence of the magnetic nanoparticles on the microgels altered their swelling behavior and shifted their volume phase transition temperature to higher values. In particular, for inorganic shells with 18% (w/w) of magnetic nanoparticles the volume phase transition of the microgels was shifted from 36 to 40 °C. In contrast, for shells consisting of 38% (w/w) magnetic nanoparticles the volume phase transition of the microgels was almost blocked, thus indicating that the microgel thermal response was strongly affected by the presence of the inorganic nanoparticles. The synthesized thermosensitive magnetic microgels are envisaged to be ideal for potential applications as thermosensitive targeted drug delivery systems.
Key words: Magnetic nanoparticles • Superparamagnetic γ-Fe2O3 iron oxide • Thermosensitive • Microgels • Drug delivery • PNIPAM
¹ Leibniz-Institut fuer Polymerforschung Dresden, Hohe Strasse 6, Dresden 01069, Germany, and Departamento Quimica Fisica II, Facultad de Farmacia, UniVersidad Complutense, 28040 Madrid, Spain.Contact us
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